Unchained Labs is a life science tools company that creates innovative, high-throughput biologics and gene therapy characterization platforms. They build tools specifically designed to help researchers break free from slow, manual lab workflows.
Core Problem Solved
Traditional analytical workflows require massive sample volumes and separate instruments. Unchained Labs solves this by engineering "problem-solving” tools that use microfluidics, automation and advanced optics. These platforms require minimal sample sizes while delivering multiple data points simultaneously.
The only plate-based dynamic light scattering & UV/Vis tool built for biologics.
Size & polydispersity: See whether your protein’s diameter is what you expect and how uniform it is — critical for screening, formulation, and QC
Aggregate detection: Flag unwanted particles and samples that have gone south, so you can fix issues fast
Protein concentration: Get extremely accurate quantification based on sample absorbance across a huge range from 0.03-275 mg/mL – while also seeing when impurities are lurking
Conjugate characterization: Gain clarity on ADC samples with DAR characterization that is ideal for high-throughput optimization
B22 & kD: Get early insight into colloidal stability based on protein self-interactions, helping predict protein stability and the impact of different formulations
The only plate-based dynamic light scattering, UV/Vis and fluorescence tool built for LNPs.
Size & polydispersity: See whether your LNP’s diameter is what you expect and how uniform it is — critical for screening, formulation, and QC
Encapsulation efficiency: Combine free RNA quantification from fluorescence and total RNA quantification from UV/Vis to make EE% characterization extra easy, detergent-free, and ready for high-throughput
Particle concentration: Sum up the total number of LNPs present in your samples to compare LNP production from one condition or batch to any other
Aggregate detection: RADLS is the most sensitive way to pick up on unwanted particles and samples that have gone south, so you can fix issues fast
Conjugate characterization: See how much protein is along for the ride by quantifying protein concentration at the same time you’re characterizing your LNP
The low-volume, plate-based UV/Vis tool for biologics & genomics.
Protein quantification: Measure protein concentration across an unmatched range of 0.03–275 mg/mL with full-spectrum UV/Vis data - ideal for formulation, conjugation, and purity checks
Nucleic Acid Concentration: Quantify DNA or RNA from 1.5–13,750 ng/µL with precision, no dilutions needed — critical for genomics workflows and QC
Contaminant detection: Identify and quantify impurities like buffer components or co-purified proteins using Unmix deconvolution algorithms — ensuring your results are clean and reliable
The ultimate tool for single-particle biophysical characterization of lentivirus & exosomes from crude or purified samples.
Lenti quality from crude samples: Measure the size and purity of lentivirus directly from in-process samples to catch poor-quality batches early in development
Exosome results from biofluids: Detect and characterize exosomes straight from serum, CSF or other biofluid — no isolation step needed — so rare populations aren’t lost
Custom capture: Use your own antibodies to capture specific viral vectors or EV subtypes for tailored biomarker or cargo analysis
Sub-population analysis: Co-localize fluorescence markers to see which particles carry payload, have intact capsid, or express specific surface proteins
Particle sizing: Determine particle size and size distribution to verify batch consistency and cargo integrity
Contaminant detection: Quantify free pP24 capsid or co-purifying EVs to fine-tune purification and improve QC
The first fully automated, plate-based, benchtop buffer exchange system.
Plates or single samples: Run 96- or 24-well plates or 1-6 single samples.
Parallel processing with flexible volumes: 96-well plates can handle 100 – 450 µL while 24-well plates and single samples hold from 0.45 - 8 mL of each sample.
Stellar recoveries: Get ≥96% of your sample back during buffer exchange or concentration.
Concentration with full process control: Concentrate samples with precise, automated final volume control.
Durable, low-binding consumables: Choose regenerated cellulose (RC) or polyethersulfone (PES) membranes – whichever works best for your sample.
Hands-free operation: Load your samples, set up your run and let Lil’ Tuna handle the entire UF/DF process on its own.
Automation-ready: Universal API software and robot-accessible sample stage let Lil’ Tuna seamlessly integrate.
The fastest low-volume viscometer for biologics out there.
Rapid, parallel testing: Measure up to 10 samples in a minute, unlocking full viscosity and rheology profiles without slowing down development
Low sample volume: Requires as little as 35 µL per sample (even less in low-volume mode), making early-stage viscosity testing possible even when material is scarce
Broad viscosity range: Covers 0.5–150 cP, so you can characterize everything from early formulations to high-concentration biologics
Real-world temperatures: Run samples from 4–45°C, enabling measurements straight from the fridge, at ambient, or under physiological conditions
3. Lipid Nanoparticle (LNP) Development: The Sunny Suite
The primo nanoparticle synthesis platform for high-throughput formulation screening.
Microfluidic precision: Generate uniform nanoparticles with supreme consistency in controlled microfluidic flow paths – less than 1% CV over 90 runs
Low reagent consumption: Run 400 µL (3:1 ratio) experiments with as little as 100 µL per reagent input, minimizing material waste while maximizing data
Range of reusable mixers: Sunnies (microfluidic mixers) come in a range of geometries and are manufactured from glass and automatically cleaned in place after every experiment, keeping running costs and hands-on time minimal
No cross contamination: Automatic cleaning of all wetted parts of the system between every experiment ensures no reagent carry-over and guarantees high-integrity samples
Scale-ready results: Sunscreen uses the same pumps and mixers as Sunshine and Sunbather, ensuring seamless process transfer from screening to GMP
The all-purpose automated nanoparticle synthesis platform for process development & production.
From milliliters to liters: Generate quality particles from 1 mL to multiple liters with Sunshine - perfect for both process optimization and pre-clinical production
Range of reusable mixers: Sunnies (microfluidic mixers) come in a range of geometries and are manufactured from glass and automatically cleaned in place after every experiment, keeping running costs and hands-on time minimal
No cross contamination: Automatic cleaning of all wetted parts of the system between every experiment ensures no reagent carry-over and guarantees high-integrity samples
Fast, simple nanoparticles: For a quick and easy encapsulation of a single payload, Sunshine Single gets straight to the point, producing as little as 400 µL of particles in less than 5 minutes
Multi-experiment automation: Sunshine and Sunshine Lite can automatically execute a series of experiments from the same injected reagents, allowing rapid screening of process conditions to find perfect particle performance fast
Seamless transfer to GMP: Processes developed on Sunshine transfer directly to Sunbather for GMP manufacturing with identical pumps and mixers
Replaceable wetted flowpath: Fully replaceable wetted flowpaths with validated sanitization SOP and supporting extractables, bioburden and endotoxin documentation for every batch
Range of mixer types: All of the same high-quality Sunny mixers can be purchased GMP-ready, ensuring the same high-quality particles and direct transferability of a development process into a GMP environment
Seamless process transfer: Uses identical pumps and mixers as Sunshine for direct translation of development parameters from pre-clinical to clinical manufacturing
Small to mid-size GMP batches: Produces up to 1.8 L/h of nanoparticles - ideal for early-stage clinical trials or small-batch commercial production such as personalized medicines, or saRNA-LNPs. As production needs grow, Sunbathers can be run in parallel to step up throughput without needing to re-optimize
GMP-ready design: Manufactured to meet regulatory requirements with IQ/OQ at install and full Unchained Labs QMS backing to ensure full manufacturing traceablity and audit readiness.
Quality built-in: Electronic records comply with 21 CFR Part 11, ensuring secure, auditable data throughout manufacturing
