Detect and monitor vascular injury with Revvity’s IVISense™ Vascular Fluorescent Imaging Panel.
This panel of fluorescent imaging probes detects cellular and molecular players in vascular pathology, enabling non-invasive in vivo characterization of biological changes associated with disease progression or treatment efficacy.
Vascular injury can have numerous causes, including peripheral vascular disease, thrombosis, aneurysm, atherosclerosis, and drug induced vascular injury. Vascular injury may progress into changes in vascular integrity, remodeling, inflammation, and fibrosis. This panel of fluorescent imaging probes detects cellular and molecular players in vascular pathology, allowing the ability to non-invasively characterize biological changes associated with disease progression or treatment efficacy.
The availability of probes at 680 nm and 750 nm wavelengths further offer the opportunity for multiplex imaging of appropriate probe combinations to maximize information gained from research animals.
The IVISense vascular fluorescent imaging panel includes the following five probes
| Part number | Fluorescent probe | Biological target |
|---|
| NEV10054EX | IVISense Vascular 680 (AngioSense 680EX) | Vascular probe:
Provides vascular contrast or vascular leak imaging |
| NEV10168 | IVISense MMP 750 FAST (MMPSense 750 FAST) | Pan-MMP activatable probe:
Secreted protease involved in vascular remodeling and angiogenesis
Secreted by vascular inflammatory cells |
| NEV10645 | IVISense Integrin Receptor 680 (IntegriSense 680) | αVβ3 integrin targeted probe:
Marker on neovasculature and inflammatory cells involved in vascular inflammation |
| NEV11112 | IVISense Cat B 680 FAST (Cat B 680 FAST) | Cathepsin B activatable probe:
Lysosomal marker of cells in vascular inflammation |
| NEV11171 | IVISense Pan Cathepsin 750 FAST (ProSense 750 FAST) | Pan-cathepsin activatable probe:
Lysosomal marker of inflammatory cells in vascular inflammation |
For research use only. Not for use in diagnostic procedures.
