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Zirconium-89-Monday Calibration

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SKU NEZ308000MC

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Visualize and quantify uptake of monoclonal antibodies (mAbs) using Zirconium-89 (89Zr). With a long-lived half-life of (3.3 days), 89Zr is well suited as a PET Imaging biomarker to access target expression as well as tumor targeting of mAbs. Zirconium-89 radionuclide is dispensed as Monday calibration in Europe and Asia. 89Zr is particularly suitable for PET imaging of internalizing mAbs. 89Zr-immuno-PET can offer excellent sensitivity and accurate quantification of mAbs or mAb-fragments in pre-clinical in vivo models. 89Zr's physical half-life of 78.4 hr matches the biological half-life of a mAb, as well as the time it needs to perfectly reach optimal target-to-non-target ratios. Literature suggests that PET image quality is not disturbed by the decay of this residualizing isotope. Zr-89 contains residual quantities of 88Y (t1/2=106.6 days) and 88Zr (t1/2=83.4 days) and must be discarded in accordance with all applicable local regulations. Manufactured by BV Cyclotron VU, De Boelelaan 1081 HV Amsterdam, The Netherlands, for PerkinElmer, under GMP Directive 2003/94/EC. CAUTION: Contains a new drug for investigational use only in laboratory research animals, or for tests in vitro. Not for use in humans.

Specifications

Specifications
Detection Method

Radiometric

Product Brand Name

NEN Radiochemicals

Radioisotope

Zr-89

Radionuclide

89Zr

Shipping Condition

Ambient

Special Ordering Information

This is a radioactive product - shipping address must have a license to receive radioactive materials.

Size

mCi

Documents

In_Vivo_Agents.pdf

Perkin Elmer In Vivo Imaging Agents Brochure

EN | 4,238 MB

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